Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection

Steven M Kent; Allen J Taylor

doi:10.1016/j.amjcard.2003.07.040

Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection

Am J Cardiol. 2003 Nov 15;92(10):1224-7. doi: 10.1016/j.amjcard.2003.07.040.

Authors

Steven M Kent¹, Allen J Taylor

Affiliation

¹ Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. [email protected]

PMID: 14609606
DOI: 10.1016/j.amjcard.2003.07.040

Abstract

C-reactive protein levels may identify patients likely to benefit from lowering low-density lipoprotein (LDL) cholesterol to ultra-low levels. We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defined optimal LDL cholesterol (<100 mg/dl) but not if LDL cholesterol is <70 mg/dl.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Aged
Atorvastatin
C-Reactive Protein / metabolism*
Carotid Arteries / drug effects
Carotid Artery Diseases / blood
Carotid Artery Diseases / drug therapy*
Cholesterol, LDL / blood*
Female
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Male
Middle Aged
Patient Selection*
Pravastatin / therapeutic use*
Pyrroles / therapeutic use*
Tunica Intima / drug effects
Tunica Media / drug effects

Substances

Cholesterol, LDL
Heptanoic Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pyrroles
C-Reactive Protein
Atorvastatin
Pravastatin