Abstract
A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Enterococcus faecalis / drug effects
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Methyl Ethers / chemical synthesis
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Methyl Ethers / pharmacology
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Microbial Sensitivity Tests
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Ristocetin / analogs & derivatives*
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Ristocetin / chemical synthesis
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Ristocetin / pharmacology
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Teicoplanin / analogs & derivatives*
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Teicoplanin / chemical synthesis
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Teicoplanin / pharmacology
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Vancomycin / analogs & derivatives*
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Vancomycin / chemical synthesis
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Vancomycin / pharmacology
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Vancomycin Resistance
Substances
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Anti-Infective Agents
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Methyl Ethers
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Ristocetin
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Teicoplanin
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Vancomycin