Changes of AFPmRNA in blood after percutaneous ethanol injection treatment of hepatocellular carcinoma

Hepatobiliary Pancreat Dis Int. 2002 May;1(2):243-5.

Abstract

Objective: To study the effects of percutaneous ethanol injection (PEI) in treatment of hepatocellular carcinoma (HCC).

Methods: Blood samples were taken from 9 HCC patients and detected by nested RT-PCR to find out AFPmRNA after PEI treatment 3-5 times within 2 weeks.

Results: Three (44.44%) of 4 patients with AFPmRNA positive turned to be negative after PEI treatment and 1 with AFPmRNA positive (11.11%) lasted within 2 weeks.

Conclusion: PEI may diminish the possibility of distant metastasis of HCC.

MeSH terms

  • Administration, Cutaneous
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / metabolism*
  • Ethanol / administration & dosage*
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / metabolism*
  • Polymerase Chain Reaction
  • RNA, Messenger / blood*
  • alpha-Fetoproteins / genetics*

Substances

  • RNA, Messenger
  • alpha-Fetoproteins
  • Ethanol