Abstract
The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes.
MeSH terms
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Animals
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Crystallography, X-Ray
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DNA / chemistry
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DNA / metabolism
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / metabolism*
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Models, Molecular
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Promoter Regions, Genetic / genetics
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Protein Conformation
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Protozoan Proteins / chemistry*
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Protozoan Proteins / metabolism*
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RNA Polymerase II / metabolism
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Substrate Specificity
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Transcription Initiation Site
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Transcription, Genetic / genetics*
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Trichomonas vaginalis / chemistry*
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Trichomonas vaginalis / genetics*
Substances
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DNA-Binding Proteins
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IBP39 protein, Trichomonas vaginalis
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Protozoan Proteins
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DNA
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RNA Polymerase II