Abstract
In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia. These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Disease Models, Animal
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Enzyme Inhibitors / pharmacology
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Hyperalgesia / chemically induced
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Hyperalgesia / enzymology
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Hyperalgesia / physiopathology
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Immunohistochemistry
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Inflammation / enzymology*
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Inflammation / physiopathology
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Inflammation Mediators / pharmacology
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Male
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Mice
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Mice, Inbred ICR
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Neuralgia / enzymology*
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Neuralgia / physiopathology
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Pain Threshold / drug effects
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Pain Threshold / physiology
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Peripheral Nervous System Diseases / enzymology*
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Peripheral Nervous System Diseases / physiopathology
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Posterior Horn Cells / cytology
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Posterior Horn Cells / enzymology
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Protein Kinase C / antagonists & inhibitors
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Protein Kinase C / metabolism*
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Reaction Time / drug effects
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Reaction Time / physiology
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Sciatic Neuropathy / enzymology
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Sciatic Neuropathy / physiopathology
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Spinal Cord / cytology
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Spinal Cord / enzymology*
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Up-Regulation / drug effects
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Up-Regulation / physiology
Substances
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Enzyme Inhibitors
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Inflammation Mediators
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Cyclic AMP-Dependent Protein Kinases
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Protein Kinase C