A new synthetic approach to the C ring of known as well as novel bryostatin analogues

Paul A Wender; Michael F T Koehler; Martin Sendzik

doi:10.1021/ol0355332

A new synthetic approach to the C ring of known as well as novel bryostatin analogues

Org Lett. 2003 Nov 27;5(24):4549-52. doi: 10.1021/ol0355332.

Authors

Paul A Wender¹, Michael F T Koehler, Martin Sendzik

Affiliation

¹ Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. [email protected]

PMID: 14627380
DOI: 10.1021/ol0355332

Abstract

[reaction: see text] A new approach to the synthesis of the C ring subunit of known and potential bryostatin analogues is described. The convergent approach, illustrated above, requires fewer steps and offers greater flexibility in rapidly accessing diverse C ring analogues.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry*
Bryostatins
Lactones / chemical synthesis*
Lactones / chemistry*
Macrolides
Molecular Structure

Substances

Antineoplastic Agents
Bryostatins
Lactones
Macrolides
bryostatin 1

Grants and funding

CA31845/CA/NCI NIH HHS/United States