Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea

Emiliano Manzo; Rob van Soest; Lohi Matainaho; Michel Roberge; Raymond J Andersen

doi:10.1021/ol035721s

Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea

Org Lett. 2003 Nov 27;5(24):4591-4. doi: 10.1021/ol035721s.

Authors

Emiliano Manzo¹, Rob van Soest, Lohi Matainaho, Michel Roberge, Raymond J Andersen

Affiliation

¹ Department of Chemistry, Earth and Ocean Sciences, University of British Columbia, Vancouver, Canada.

PMID: 14627391
DOI: 10.1021/ol035721s

Abstract

[structure: see text] Two novel antimitotic heterocyclic alkaloids, ceratamines A (1) and B (2), have been isolated from the marine sponge Pseudoceratina sp., collected in Papua New Guinea. The structures of 1 and 2 were elucidated by analysis of spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / biosynthesis
Alkaloids / chemistry*
Alkaloids / isolation & purification*
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification*
Azepines / chemistry*
Azepines / isolation & purification*
Azepines / metabolism
Imidazoles / chemistry*
Imidazoles / isolation & purification*
Imidazoles / metabolism
Isomerism
Magnetic Resonance Spectroscopy
Molecular Structure
Papua New Guinea
Porifera / chemistry*

Substances

Alkaloids
Antineoplastic Agents
Azepines
Imidazoles
ceratamine A
ceratamine B