Abstract
Intrarenal infusion of a low dose of bradykinin devoid of extrarenal action exerts direct vasodilator and diuretic effects on rat kidney. It does not significantly alter glomerular filtration rate and absolute proximal reabsorption but increases the delivery of fluid from the proximal tubule evaluated by the clearance of lithium. None of these effects are observed in kidneys infused with both bradykinin and a specific bradykinin antagonist.
MeSH terms
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Animals
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Bradykinin / analogs & derivatives*
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Bradykinin / antagonists & inhibitors
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Bradykinin / pharmacology*
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Glomerular Filtration Rate / drug effects*
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Kidney / blood supply
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Kidney / drug effects
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Kidney / physiology*
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Kidney Tubules, Proximal / drug effects*
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Kidney Tubules, Proximal / physiology
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Lithium / metabolism
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Male
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Rats
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Rats, Inbred WKY
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Regional Blood Flow / drug effects
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Renal Circulation / drug effects*
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Urine / physiology
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p-Aminohippuric Acid
Substances
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Lithium
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NPC 567
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Bradykinin
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p-Aminohippuric Acid