Abstract
We performed a retrospective study of a series of 58 of 189 vertically HIV-1 infected children who went on to develop progressive HIV-1-associated encephalopathy to assess real-life effects of early antiretroviral therapy on neurologic outcome. Our findings clearly indicate that antiretroviral therapy before the onset of neurologic symptoms delayed presentation of progressive HIV-1-associated encephalopathy, with an additional beneficial effect on survival.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Dementia Complex / drug therapy
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AIDS Dementia Complex / prevention & control*
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Anti-Retroviral Agents / pharmacology
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Anti-Retroviral Agents / therapeutic use*
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Child
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Child, Preschool
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Female
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HIV Infections / drug therapy
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HIV Infections / prevention & control*
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HIV-1 / drug effects
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Humans
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Infant
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Infectious Disease Transmission, Vertical / prevention & control*
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Male
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Neuroprotective Agents / pharmacology
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Neuroprotective Agents / therapeutic use*
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Proportional Hazards Models
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Retrospective Studies
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Statistics, Nonparametric
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Survival Analysis
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Time Factors
Substances
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Anti-Retroviral Agents
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Neuroprotective Agents