Cdk5 and the mystery of synaptic vesicle endocytosis

J Cell Biol. 2003 Nov 24;163(4):697-9. doi: 10.1083/jcb.200310038.

Abstract

Regulation of endocytosis by protein phosphorylation and dephosphorylation is critical to synaptic vesicle recycling. Two groups have now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of this process. Robinson and coworkers recently demonstrated that Cdk5 is necessary for synaptic vesicle endocytosis (SVE) (Tan et al., 2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases / metabolism*
  • Dynamins / metabolism
  • Endocytosis / physiology*
  • Feedback, Physiological / physiology
  • Humans
  • Models, Biological
  • Phosphorylation
  • Presynaptic Terminals / enzymology*
  • Presynaptic Terminals / ultrastructure
  • Synaptic Vesicles / enzymology*
  • Synaptic Vesicles / ultrastructure

Substances

  • Cyclin-Dependent Kinase 5
  • CDK5 protein, human
  • Cyclin-Dependent Kinases
  • Dynamins