Abstract
Three new bromotyrosine derivatives (4-6) were isolated from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis, along with the previously described (E,E)-psammaplin A (1), (E,Z)-psammaplin A (2), psammaplin D (3), bisaprasin (7), and (3-bromo-4-hydroxyphenyl)acetonitrile (8). The structures of the new compounds were established on the basis of NMR and MS spectroscopic analysis. The compounds 1, 3, and 5-7 displayed significant cytotoxicity against human lung (A549), ovarian (SK-OV-3), skin (SK-MEL-2), CNS (XF498), and colon (HCT15) cancer cell lines. Compounds 3-7 were further evaluated for antibacterial activity against methicillin- or ofloxacin-resistant Staphylococcus strains. Compound 4 exhibited more potent antibacterial activity than meropenem against several strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Central Nervous System Neoplasms
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Colonic Neoplasms
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Disulfides / chemistry
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Disulfides / isolation & purification
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Disulfides / pharmacology
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Drug Screening Assays, Antitumor
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Electron Spin Resonance Spectroscopy
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Female
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Humans
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Korea
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Lung Neoplasms
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Methicillin Resistance
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Microbial Sensitivity Tests
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Ofloxacin / pharmacology
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Ovarian Neoplasms
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Porifera / chemistry*
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Skin Neoplasms
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Staphylococcus / drug effects
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Tumor Cells, Cultured / drug effects
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Tyrosine / analogs & derivatives*
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Tyrosine / chemistry
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Tyrosine / isolation & purification
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Tyrosine / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Disulfides
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bromotyrosine
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psammaplin A
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Tyrosine
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Ofloxacin