Highly stereoselective synthesis of (-)-monatin, a high-intensity sweetener, using chelation-controlled nitrone cycloaddition

Chem Commun (Camb). 2003 Nov 7:(21):2678-9. doi: 10.1039/b306791m.

Abstract

Synthesis of (-)-monatin was achieved by chelation-controlled cycloaddition of nitrone 2 with allyl alcohol 3a in the presence of MgBr2-OEt2.