Synthesis of hydroxymethyl branched [3.2.0]bicyclic nucleosides using a regioselective oxetane ring-formation

Org Biomol Chem. 2003 Nov 7;1(21):3738-48. doi: 10.1039/b307667a.

Abstract

Two [3.2.0]bicyclic nucleosides, 35 and 34, with one and two hydroxymethyl substituents, respectively, have been efficiently synthesized. A protected (3'-C-vinyl-beta-D-allofuranosyl)thymine derivative 28 was easily prepared from diacetone-D-glucose and the thymine moiety was protected with a BOM-group. After the introduction of a leaving group in the 2'-position, the subsequent nucleoside 31 was used as the substrate for a stereoselective dihydroxylation and a regioselective oxetane ring-formation to give after deprotection the bicyclic nucleoside 34. The surprisingly efficient formation of an oxetane was first discovered by serendipity on a corresponding methylfuranoside derivative. The allo-configured bicyclic nucleoside 34 was easily shortened to a ribo-configured analogue 35 by a diol-cleaving reaction and subsequent reduction. Both 34 and 35 are conformationally restricted in the important intermediate 04'-endo conformation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ethers, Cyclic / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry

Substances

  • Ethers, Cyclic
  • Nucleosides
  • oxetane