Abstract
The effects of palm carotene on chemical carcinogenesis was studied. Palm carotene suppressed mouse epidermal ornithine decarboxylase activity induced by glycocholic acid. In a two-stage mouse epidermal carcinogenesis experiment using 7,12-dimethylbenz(a)anthracene as the initiator, glycocholic acid as the 1st stage promoter, and mezerein as the 2nd stage promoter, palm carotene inhibited the promoting activity of glycocholic acid. Furthermore, in N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis, 0.05% of palm carotene given in drinking water decreased the percentage of tumor-bearing mice significantly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Carcinogens / toxicity
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Carotenoids / therapeutic use*
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Diterpenes*
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Duodenal Neoplasms / chemically induced
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Duodenal Neoplasms / prevention & control*
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Female
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Glycocholic Acid / toxicity*
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Male
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Methylnitronitrosoguanidine / analogs & derivatives
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Mice
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Mice, Inbred C57BL
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Mice, Inbred ICR
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Ornithine Decarboxylase / analysis
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Skin Neoplasms / chemically induced
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Skin Neoplasms / prevention & control*
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Terpenes / toxicity
Substances
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Carcinogens
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Diterpenes
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Terpenes
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Methylnitronitrosoguanidine
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mezerein
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Carotenoids
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ENNG
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9,10-Dimethyl-1,2-benzanthracene
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Ornithine Decarboxylase
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Glycocholic Acid