Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine

Methods Mol Med. 2004:90:263-78. doi: 10.1385/1-59259-429-8:263.
No abstract available

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / pharmacokinetics*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Biotransformation
  • Cell Line
  • Coculture Techniques
  • DNA, Complementary / pharmacokinetics
  • Floxuridine / administration & dosage
  • Floxuridine / pharmacokinetics*
  • Floxuridine / therapeutic use
  • Fluorouracil / pharmacokinetics
  • Genetic Therapy / methods*
  • Genetic Vectors
  • Humans
  • Mammals
  • Restriction Mapping
  • Thymidine Phosphorylase / genetics*
  • Thymidine Phosphorylase / metabolism*
  • Transfection / methods*
  • Tritium
  • Tumor Cells, Cultured

Substances

  • Antimetabolites, Antineoplastic
  • DNA, Complementary
  • Floxuridine
  • Tritium
  • Thymidine Phosphorylase
  • Fluorouracil