To investigate the long-term survival of 95 patients treated by home mechanical ventilation, we prospectively analyzed the outcomes of their cases (treatments: 34, tracheostomy; 61, non-invasive methods) using the database of the local registration system in Aichi Prefecture. The annual actuarial probability of continuing home mechanical ventilation for the tracheostomized patients was 97.0% in the first year, 79.0% in the second year, 79.0% in the third year, and 69.2% in the fourth year, and those for the patients treated by non-invasive ventilation were 85.6%, 67.9%, 56.8%, and 46.4%, respectively. In comparison with patients with neuromuscular disease, patients with respiratory disease (both tracheostomized and non-tracheostomized) tended to show a lower continuation ratio, but the difference was not statistically significant. These data were comparable to those of previous reports, suggesting that home respiratory care in Aichi Prefecture satisfied the normal standards of quality.