Abstract
Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Encephalomyocarditis virus / drug effects
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Encephalomyocarditis virus / growth & development
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Herpesvirus 1, Human / drug effects
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Herpesvirus 1, Human / growth & development
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Herpesvirus 2, Human / drug effects
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Herpesvirus 2, Human / growth & development
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology*
Substances
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Antiviral Agents
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Nucleosides