Bradykinin antagonists do not require a D-aromatic amino acid residue at position 7

Agents Actions Suppl. 1992:38 ( Pt 1):572-81. doi: 10.1007/978-3-0348-7321-5_70.

Abstract

More than 200 new analogs of bradykinin have been synthesized and assayed. Analogs containing a D-aliphatic amino acid residue at position 7 and an L-aliphatic residue at position 8 are very potent antagonists of BK action on classical systems. Thus the "conventional wisdom" that a D-aromatic amino acid residue is required at sequence position 7 of BK antagonists must be modified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blood Pressure / drug effects
  • Bradykinin / analogs & derivatives
  • Bradykinin / antagonists & inhibitors*
  • Bradykinin / chemistry
  • Female
  • Guinea Pigs
  • Ileum / drug effects
  • In Vitro Techniques
  • Molecular Sequence Data
  • Rats
  • Structure-Activity Relationship
  • Uterus / drug effects

Substances

  • Bradykinin