Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer

Riad Haddad; John B Vincent; Robert Gryfe; Hyeja Kim; Joseph Wen; Mark Redston; Stephen W Scherer; Steven Gallinger

doi:10.1016/j.canlet.2003.08.003

Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer

Cancer Lett. 2004 Jan 8;203(1):87-90. doi: 10.1016/j.canlet.2003.08.003.

Authors

Riad Haddad¹, John B Vincent, Robert Gryfe, Hyeja Kim, Joseph Wen, Mark Redston, Stephen W Scherer, Steven Gallinger

Affiliation

¹ Department of Surgery, Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Ave, Suite 1225, Toronto, Ont. M5G IX5, Canada.

PMID: 14670621
DOI: 10.1016/j.canlet.2003.08.003

Abstract

ST7 is a putative tumor suppressor gene on chromosome 7q31. However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate. In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized. No somatic mutations of the RAY1/ST7 gene were observed. Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / genetics*
Allelic Imbalance*
Chromosomes, Human, Pair 7
Colorectal Neoplasms / genetics*
Humans
Mutation
Proteins / genetics*
Tumor Suppressor Proteins / genetics*

Substances

Proteins
ST7 protein, human
Tumor Suppressor Proteins