Homelessness is a rising problem with socioeconomic roots that affects millions of people around the world. Homeless people suffer from a wide range of health problems and, consequently, have high rates of morbidity and mortality. Various infectious and noninfectious skin conditions have been described among the homeless, with trauma, superficial fungal infections, and foot problems being the most prevalent. Poor hygiene conditions, exposure to harmful environmental agents, and impaired access to health care may further exacerbate these skin diseases and lead to serious and occasionally life-threatening situations. As an integral part of the medical care for the homeless, dermatologic care is essential in diagnosing and managing their skin diseases, in preventing more serious complications and in improving the overall health status of the homeless population.