Using the Diagnostic Assessment of the Severely Handicapped-II (DASH-II) to measure the therapeutic effects of risperidone

J Intellect Disabil Res. 2004 Jan;48(1):53-9. doi: 10.1111/j.1365-2788.2004.00583.x.

Abstract

Background: Within the scope of a double-blind, placebo-controlled, crossover medication study, the Diagnostic Assessment of the Severely Handicapped-II (DASH-II) was evaluated as a measurement for determining the effectiveness of the medication risperidone in treating the problem behaviour of 21 people with intellectual disabilities (ID).

Method: Participants' caregivers completed the DASH-II during the placebo/baseline phase of the study and the maintenance phase of the study, and completed the Aberrant Behavior Checklist - Community (ABC-C) weekly throughout the entire study. The results obtained using the DASH-II were compared to those obtained using the ABC-C, an instrument shown to be well correlated with the DASH-II.

Results: Results suggest that while the DASH-II and the ABC-C were well correlated during the placebo/baseline phase of the current study, they were not well correlated at completion of the 6-month maintenance phase of the medication trial.

Conclusion: The DASH-II, while appropriate for assisting in the diagnosis of psychopathology in people with ID, does not appear to monitor changes in problem behaviour as a result of risperidone use as well as the ABC-C. Differences in the frequency of problem behaviour that each measure evaluated and the applicability of using the DASH-II to measure medication effects on problem behaviour are discussed.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antipsychotic Agents / therapeutic use*
  • Cross-Over Studies
  • Double-Blind Method
  • Humans
  • Mental Disorders / classification
  • Mental Disorders / diagnosis*
  • Mental Disorders / drug therapy*
  • Persons with Disabilities*
  • Risperidone / therapeutic use*
  • Severity of Illness Index
  • Surveys and Questionnaires*
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Risperidone