This study describes the prevalence of and investigates variables associated with problems in sexual functioning for a sample of 347 individuals following renal transplantation. Sexual problem was conceptualized through three continuous variables: lack of interest in sex; lack of enjoyment of sex; and difficulty becoming sexually aroused. Between 50 percent and 55 percent of respondents reported no sexual difficulties. The remaining respondents indicated from mild to severe problems. Multiple regression was used to examine predictors of problems with sexual functioning. Variables in the final model associated with sexual problems were older age and lower patient perceptions of physical and mental well-being. Assessment of and education regarding sexual functioning must be a routine component of psychosocial intervention. Future research warrants investigation of the meaning of sexual function for this population.