Abstract
1. Mytilus pedal ganglion contains a small population of glial cells that are immunopositive for interleukin-1 alpha. Positively stained fibers can also be seen in the neuropil of these sections. 2. The marine worm Nereis diversicolor also exhibits positive neural immunostaining for interleukin-1 alpha. 3. Both organisms contain hemocytes that contain immunoactivity for interleukin-1 alpha. The study suggests interleukin-1 alpha to be an ancient cytokine given its presence in organisms that evolved significantly earlier than mammals.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Biological Evolution
-
Bivalvia / anatomy & histology*
-
Bivalvia / chemistry
-
Enkephalin, Methionine / analogs & derivatives
-
Enkephalin, Methionine / pharmacology
-
Ganglia / chemistry
-
Ganglia / cytology*
-
Ganglia / drug effects
-
Gene Expression Regulation / drug effects
-
Hemocytes / chemistry*
-
Image Processing, Computer-Assisted
-
Interleukin-1 / analysis*
-
Nerve Tissue Proteins / analysis*
-
Neuroglia / chemistry*
-
Neuroglia / drug effects
-
Polychaeta / anatomy & histology*
-
Polychaeta / chemistry
Substances
-
Interleukin-1
-
Nerve Tissue Proteins
-
enkephalin, delta-Ala(2)-Met(5)-
-
Enkephalin, Methionine