Difference in mGluR5 interaction between positive allosteric modulators from two structural classes

Ann N Y Acad Sci. 2003 Nov:1003:481-4. doi: 10.1196/annals.1300.059.

Authors

David L Williams Jr¹, Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S L Chang, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski, Craig W Lindsley, Cyrille Sur, Mark E Duggan, Douglas J Pettibone, P Jeffrey Conn

Affiliation

¹ Department of Neuroscience-WP, Merck Research Laboratories, West Point, Pennsylvania and Rahway, New Jersey. [email protected]

PMID: 14684495
DOI: 10.1196/annals.1300.059

No abstract available

MeSH terms

Animals
Benzamides / pharmacology
Binding Sites
CHO Cells
Cricetinae
Excitatory Amino Acid Agonists / chemistry
Excitatory Amino Acid Agonists / pharmacology*
Excitatory Amino Acid Antagonists / chemistry
Excitatory Amino Acid Antagonists / pharmacology*
Glycine / analogs & derivatives*
Glycine / pharmacology
Humans
Hydrazines / pharmacology
Phthalimides / pharmacology
Rats
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate / chemistry
Receptors, Metabotropic Glutamate / drug effects*
Resorcinols / pharmacology
Structure-Activity Relationship

Substances

3,3'-difluorobenzaldazine
Benzamides
Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
GRM5 protein, human
Grm5 protein, rat
Hydrazines
N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide
Phthalimides
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate
Resorcinols
3,5-dihydroxyphenylglycine
Glycine