Abstract
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. The health of ATL patients rapidly deteriorates resulting in death; however, the induction of death in a small animal model due to tumor has not yet been reported. SCID mice, 5 weeks old, younger than those previously used, which were inoculated with ATL cells, eliminated NK cell activity and showed rapid tumor formation resulting in death. Age is the crucial factor influencing tumor formation and death in the SCID mice model for cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Animals
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Beta-Globulins / analysis
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Beta-Globulins / genetics
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Cell Transformation, Viral
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DNA, Neoplasm / analysis
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Gene Products, tax / analysis
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Gene Products, tax / genetics
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HTLV-I Infections*
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Human T-lymphotropic virus 1 / genetics*
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Human T-lymphotropic virus 1 / immunology
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Immunocompromised Host*
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Killer Cells, Natural / immunology
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Leukemia, T-Cell* / immunology
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Leukemia, T-Cell* / mortality
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Leukemia, T-Cell* / virology
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Male
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Mice
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Mice, SCID
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Polymerase Chain Reaction
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Survival Rate
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Xenograft Model Antitumor Assays*
Substances
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Beta-Globulins
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DNA, Neoplasm
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Gene Products, tax