Abstract
The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 (Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission. Both drugs had a favorable therapeutic index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented cell-free HIV infection, whereas 10-fold-higher concentrations blocked cell-associated HIV.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anilides / pharmacology*
-
Anti-HIV Agents / pharmacology*
-
CD4-Positive T-Lymphocytes / drug effects
-
CD4-Positive T-Lymphocytes / virology
-
Cell-Free System
-
Cells, Cultured
-
Coculture Techniques
-
Dendritic Cells / virology
-
Enzyme-Linked Immunosorbent Assay
-
Furans / pharmacology*
-
HIV Infections / prevention & control*
-
HIV Infections / virology
-
HIV-1
-
Humans
-
Pyrimidines / pharmacology
-
Reverse Transcriptase Inhibitors / pharmacology*
-
Thioamides
Substances
-
Anilides
-
Anti-HIV Agents
-
Furans
-
Pyrimidines
-
Reverse Transcriptase Inhibitors
-
Thioamides
-
UC-781
-
Dapivirine