Comparison of in vitro activities of ketolides, macrolides, and an azalide against the spirochete Borrelia burgdorferi

Antimicrob Agents Chemother. 2004 Jan;48(1):344-7. doi: 10.1128/AAC.48.1.344-347.2004.

Abstract

Two ketolides, three macrolides, and one azalide were tested in vitro against 17 isolates of the B. burgdorferi s.l. complex. As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC(90)], 0.0019 micro g/ml) and telithromycin (MIC(90), 0.0078 micro g/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Aza Compounds / pharmacology*
  • Borrelia burgdorferi / drug effects*
  • Borrelia burgdorferi / ultrastructure
  • Erythromycin / analogs & derivatives
  • Erythromycin / pharmacology
  • Humans
  • Ketolides*
  • Lyme Disease / microbiology
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Aza Compounds
  • Ketolides
  • Macrolides
  • Erythromycin
  • cethromycin
  • telithromycin