Abstract
This experiment examined the effects of co-infusing the GABA agonist muscimol (0.5 nmol) with 33 nmol of glucose, pyruvate, fructose or sorbitol into the medial septum on spontaneous alternation. Only co-infusions of muscimol with glucose or pyruvate impaired spontaneous alternation performance; none of the other infusions had any significant effects. The findings suggest that glucose metabolism rather than hyperosmolarity is involved in the memory-impairing interaction between glucose and muscimol.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Avoidance Learning / drug effects
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Avoidance Learning / physiology
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Fructose / administration & dosage
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Fructose / pharmacology
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GABA Agonists / administration & dosage
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GABA Agonists / pharmacology*
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Glucose / administration & dosage
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Glucose / pharmacology*
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Injections, Intraventricular
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Male
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Maze Learning / drug effects
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Maze Learning / physiology
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Memory / drug effects*
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Memory / physiology
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Muscimol / administration & dosage
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Muscimol / pharmacology
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Pyruvic Acid / administration & dosage
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Pyruvic Acid / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Septal Nuclei / drug effects*
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Septal Nuclei / physiology
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Sorbitol / administration & dosage
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Sorbitol / pharmacology
Substances
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GABA Agonists
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Muscimol
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Fructose
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Sorbitol
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Pyruvic Acid
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Glucose