Abstract
The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord. Mice with sciatic nerve ligation exhibited a significant suppression of the morphine-induced antinociception. Under this condition, phosphorylated-mu-opioid receptor-like immunoreactivity was clearly increased on the ipsilateral side in the superficial laminae of the L5 lumbar spinal dorsal horn in nerve-ligated mice. These findings suggest that the phosphorylation of the mu-opioid receptor in the spinal cord under a neuropathic pain-like state may, at least in part, contribute to the reduction in the antinociceptive effect produced by morphine in the mouse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Afferent Pathways / drug effects
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Afferent Pathways / metabolism
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Afferent Pathways / physiopathology
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Animals
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Disease Models, Animal
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Functional Laterality / physiology
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Ligation
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Male
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Mice
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Mice, Inbred ICR
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Morphine / pharmacology
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Neuralgia / drug therapy
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Neuralgia / metabolism*
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Neuralgia / physiopathology
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Peripheral Nervous System Diseases / drug therapy
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Peripheral Nervous System Diseases / metabolism*
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Peripheral Nervous System Diseases / physiopathology
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Phosphorylation / drug effects
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Posterior Horn Cells / drug effects
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Posterior Horn Cells / metabolism*
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Posterior Horn Cells / pathology
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Receptors, Opioid, mu / drug effects
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Receptors, Opioid, mu / metabolism*
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Sciatic Neuropathy / drug therapy
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Sciatic Neuropathy / metabolism
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Sciatic Neuropathy / physiopathology
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Spinal Cord / drug effects
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Spinal Cord / metabolism*
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Spinal Cord / pathology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Up-Regulation / drug effects
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Up-Regulation / physiology
Substances
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Receptors, Opioid, mu
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Morphine