CDK versus GSK-3 inhibition: a purple haze no longer?

Chem Biol. 2003 Dec;10(12):1144-6. doi: 10.1016/j.chembiol.2003.12.009.

Abstract

The ubiquitous ATP binding site offers a global target for protein kinase inhibitors. The corollary is that molecular selectivity with such agents may be difficult to achieve and ascertain. A relevant example is discussed in terms of design and biomedical rationale.

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Binding Sites
  • Cyclin-Dependent Kinases / antagonists & inhibitors*
  • Cyclin-Dependent Kinases / chemistry*
  • Cyclin-Dependent Kinases / genetics
  • Cyclin-Dependent Kinases / metabolism
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Glycogen Synthase Kinase 3 / antagonists & inhibitors*
  • Glycogen Synthase Kinase 3 / chemistry*
  • Glycogen Synthase Kinase 3 / genetics
  • Glycogen Synthase Kinase 3 / metabolism
  • Models, Molecular
  • Protein Structure, Tertiary
  • Substrate Specificity

Substances

  • Enzyme Inhibitors
  • Adenosine Triphosphate
  • Cyclin-Dependent Kinases
  • Glycogen Synthase Kinase 3