No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells

Cancer Cell. 2003 Dec;4(6):417-8. doi: 10.1016/s1535-6108(03)00305-2.

Abstract

A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Differentiation
  • Cyclin D3
  • Cyclins / metabolism*
  • Humans
  • Leukemia, T-Cell / metabolism*
  • Leukemia, T-Cell / pathology
  • Signal Transduction
  • T-Lymphocytes / cytology
  • T-Lymphocytes / metabolism*

Substances

  • CCND3 protein, human
  • Cyclin D3
  • Cyclins