This is a short report on a splenic metastasis from renal cell carcinoma. Previously, the patient had renal carcinoma removed by nephrectomy. The diagnosis of metastasis was based on morphology and immunohistochemistry. It is certainly true that splenic metastases from renal cell carcinoma are rare. Nevertheless, they have been well described in the literature. A giant cell reaction to tumor is noted in a number of cancers and mainly represents an unusual phenotype.