Abstract
The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half of cases. The potential role of the microenvironment and/or tumoral process in HLA-G expression is discussed in the light of these data. HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Division
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Enzyme-Linked Immunosorbent Assay
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Exons
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Flow Cytometry
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HLA Antigens / blood
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HLA Antigens / immunology*
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HLA Antigens / physiology*
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HLA-G Antigens
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Histocompatibility Antigens Class I / blood
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Histocompatibility Antigens Class I / immunology*
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Histocompatibility Antigens Class I / physiology*
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Humans
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Lymphoproliferative Disorders / immunology*
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Lymphoproliferative Disorders / metabolism
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Multiple Myeloma / immunology
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Protein Isoforms
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RNA, Messenger / metabolism
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Transcription, Genetic
Substances
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I
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Protein Isoforms
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RNA, Messenger