Abstract
A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoma / diagnosis
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Adenoma / immunology
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Adult
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Autoantibodies / blood*
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Autoimmune Diseases / diagnosis
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Autoimmune Diseases / immunology*
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Biomarkers, Tumor
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DNA-Binding Proteins / immunology*
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Diagnosis, Differential
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Female
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Humans
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Inflammation / diagnosis
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Inflammation / immunology
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Lymphocytes / immunology
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Male
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Middle Aged
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Phosphopyruvate Hydratase / immunology*
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Pituitary Diseases / diagnosis
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Pituitary Diseases / enzymology*
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Pituitary Diseases / immunology*
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Pituitary Neoplasms / diagnosis
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Pituitary Neoplasms / immunology
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Tumor Suppressor Proteins / immunology*
Substances
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Autoantibodies
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Biomarkers, Tumor
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DNA-Binding Proteins
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Tumor Suppressor Proteins
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ENO1 protein, human
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Phosphopyruvate Hydratase