Immunopathogenesis of cutaneous T-cell lymphomas

Hematol Oncol Clin North Am. 2003 Dec;17(6):1313-7, vii. doi: 10.1016/s0889-8588(03)00116-3.

Abstract

The physiopathology of cutaneous T-cell lymphomas is poorly understood. Little is known about the factors that drive a mature T-cell clone to accumulate in the skin, despite the feedback mechanisms that normally control immune response. This article discusses the identification of tumor-specific antigens.

Publication types

  • Review

MeSH terms

  • Antigens, CD / analysis
  • Antigens, Neoplasm / analysis*
  • Cell Line, Tumor / chemistry
  • Cell Line, Tumor / pathology
  • Humans
  • Immunophenotyping
  • Leukocyte Immunoglobulin-like Receptor B1
  • Lymphoma, T-Cell, Cutaneous / diagnosis
  • Lymphoma, T-Cell, Cutaneous / immunology
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Neoplasm Proteins / analysis
  • Neoplastic Stem Cells / chemistry
  • Neoplastic Stem Cells / pathology*
  • Receptors, Cell Surface / analysis
  • Receptors, Immunologic / analysis
  • Receptors, KIR
  • Sezary Syndrome / diagnosis
  • Sezary Syndrome / immunology
  • Sezary Syndrome / pathology
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology*
  • T-Lymphocyte Subsets / chemistry
  • T-Lymphocyte Subsets / pathology*

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • LILRB1 protein, human
  • Leukocyte Immunoglobulin-like Receptor B1
  • Neoplasm Proteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Receptors, KIR
  • SC5 receptor, human