[Concurrent chemoradiation experience of recurrent gastric cancers resistant to TS-1]

Gan To Kagaku Ryoho. 2003 Dec;30(13):2107-13.
[Article in Japanese]

Abstract

We report our experience with concurrent chemoradiation for recurrent gastric cancers resistant to TS-1. From April 2000 to March 2003, we treated 10 consecutive patients with radiation and the concurrent single chemotherapy agent of TS-1 or CPT-11. Of the 10 patients, 3 (30%) had a complete response, 4 (40%) a partial response, and 3 (30%) stable disease, yielding an overall response rate of 70% (7/10). Three patients are alive and cancer-free, 5 patients died with cancers, and 2 patients are living with cancers as outpatients. The clinical benefit response was 90% (9/10). No patient has had either acute or late complication. Concurrent chemoradiation is feasible and seems to offer good results for recurrent gastric cancers resistant to TS-1.

MeSH terms

  • Aged
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Camptothecin / administration & dosage*
  • Camptothecin / analogs & derivatives*
  • Drug Administration Schedule
  • Drug Combinations*
  • Drug Resistance, Neoplasm*
  • Female
  • Humans
  • Irinotecan
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / drug therapy*
  • Oxonic Acid*
  • Pyridines*
  • Quality of Life
  • Radiotherapy Dosage
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / radiotherapy*
  • Tegafur*

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Combinations
  • Pyridines
  • S 1 (combination)
  • Tegafur
  • Oxonic Acid
  • Irinotecan
  • Camptothecin