Dramatic response of choroidal metastases from breast cancer to a combination of trastuzumab and vinorelbine

Breast J. 2004 Jan-Feb;10(1):54-6. doi: 10.1111/j.1524-4741.2004.09614.x.

Abstract

We report the case of a 57-year-old woman with unilateral choroidal metastases from HER-2-positive breast cancer. She was given trastuzumab and vinorelbine with complete resolution of her visual defect after one cycle of treatment. This article illustrates that treatment using trastuzumab-containing chemotherapy regimens in HER-2-overexpressing breast cancer patients with choroidal metastases may be an alternative therapeutic strategy to initial orbital irradiation.

Publication types

  • Case Reports

MeSH terms

  • Angiography
  • Antibodies, Monoclonal / administration & dosage
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / complications
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / complications
  • Carcinoma, Ductal, Breast / diagnosis*
  • Carcinoma, Ductal, Breast / drug therapy
  • Carcinoma, Ductal, Breast / secondary
  • Choroid Neoplasms / diagnosis*
  • Choroid Neoplasms / drug therapy
  • Choroid Neoplasms / secondary
  • Cicatrix / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / secondary
  • Scotoma / etiology
  • Trastuzumab
  • Vinblastine / administration & dosage
  • Vinblastine / analogs & derivatives*
  • Vinorelbine

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Vinblastine
  • Trastuzumab
  • Vinorelbine