Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions

Mingji Dai; Bo Liang; Cuihua Wang; Jiahua Chen; Zhen Yang

doi:10.1021/ol036182u

Synthesis of a novel C2-symmetric thiourea and its application in the Pd-catalyzed cross-coupling reactions with arenediazonium salts under aerobic conditions

Org Lett. 2004 Jan 22;6(2):221-4. doi: 10.1021/ol036182u.

Authors

Mingji Dai¹, Bo Liang, Cuihua Wang, Jiahua Chen, Zhen Yang

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871 China.

PMID: 14723533
DOI: 10.1021/ol036182u

Abstract

[reaction: see text] A novel thiourea-based C2-symmetric ligand was synthesized, and its application in the palladium-catalyzed Heck and Suzuki coupling reactions of arenediazonium salts was evaluated. The reactions, which were performed at room temperature, without added base, and under aerobic conditions, produced product in 4 h with good yield. The corresponding arenediazonium salts were easily generated in one step from anilines.