[Inhibition of mitochondrial ATP-synthetase by redox-agents]

Biofizika. 1992 Sep-Oct;37(5):942-9.
[Article in Russian]

Abstract

Effects of phenol and phenothiazine on ATP synthesis and electron transport in submitochondrial particles were studied. Nitrophenols and phenothiazines inhibited ATP synthesis without notable effect on electron transport. On the contrary chlorphenols equally decreased the velocities of electron transport and ATP synthesis. The inhibitors studied showed the properties of electron acceptors in relation to the radicals, their acceptor properties corresponding to their ability to inhibit ATP synthesis.

Publication types

  • English Abstract

MeSH terms

  • Adenosine Triphosphatases / antagonists & inhibitors*
  • Adenosine Triphosphate / biosynthesis
  • Electron Transport
  • Mitochondria / enzymology*
  • Nitrophenols / chemistry
  • Oxidation-Reduction
  • Phenol
  • Phenols / chemistry
  • Phenothiazines / chemistry
  • Submitochondrial Particles / metabolism

Substances

  • Nitrophenols
  • Phenols
  • Phenothiazines
  • Phenol
  • Adenosine Triphosphate
  • Adenosine Triphosphatases
  • phenothiazine