Intraneural dendritic cell neurofibroma with pseudorosettes

Am J Dermatopathol. 2004 Feb;26(1):72-5. doi: 10.1097/00000372-200402000-00012.

Abstract

Dendritic cell neurofibroma with pseudorosettes (DCNWPR) is a recently proposed variant of neurofibroma. However, its peripheral nerve sheath origin has subsequently been questioned, and it has been suggested that the neoplasm could represent a hitherto undescribed variant of melanocytic nevus with neural differentiation. Here we report a case of DCNWPR that arose almost exclusively within the confinement of the perineurium in the skin. This observation gives further evidence that this entity is a peripheral nerve sheath tumor and is unrelated to melanocytic neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • CD57 Antigens / analysis
  • Dendritic Cells / chemistry
  • Dendritic Cells / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Nerve Sheath Neoplasms / chemistry
  • Nerve Sheath Neoplasms / pathology*
  • Neurofibroma / chemistry
  • Neurofibroma / pathology*
  • Peripheral Nerves / chemistry
  • Peripheral Nerves / pathology*
  • S100 Proteins / analysis

Substances

  • Biomarkers, Tumor
  • CD57 Antigens
  • S100 Proteins