PCR detection of structurally abnormal Y chromosomes

Jpn J Hum Genet. 1992 Sep;37(3):187-93. doi: 10.1007/BF01900712.

Abstract

Three probes each detecting a locus on the proximal long arm of the Y chromosome were partially sequenced. Thus, 3 sets of novel primers were developed which enable PCR detection of these 3 loci. Five previously reported primer sets, 3 on the short arm and each one on the centromere and the distal long arm, were mapped along with the novel three using a mapping panel consisted of 8 patients each with different structural abnormality of the Y chromosome. Now, PCR detection of these 8 loci covering an entire length of the Y chromosome has become possible enabling rapid screening of patients with Y chromosome aberrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Female
  • Humans
  • Male
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides
  • Polymerase Chain Reaction / methods*
  • Sex Chromosome Aberrations / genetics*
  • Y Chromosome*

Substances

  • Oligodeoxyribonucleotides