Model complexes with naturally occurring ligands (salicylglycine and imidazol) and the biometals copper and cobalt

J Inorg Biochem. 2004 Feb;98(2):413-21. doi: 10.1016/j.jinorgbio.2003.11.002.

Abstract

Two new complexes [Cu(Imz)(4)Cl(2)][Cu(Imz)(4)Cl] (2)(2-OH-Hip)(2) (1) and [Co(2-OH-Hip)(Imz)(3)].H(2)O (2) (with Imz=Imidazol and 2-OH-Hip=2-hydroxyhippuric acid) were prepared and characterized. The molecular structures and the solution and solid state behavior of the complexes were investigated. Complex 1 crystallizes in the monoclinic space group P2(1)/c with a=16.880(1), b=8.046(1), c=24.683(1) A, beta=107.88(1) degrees, and Z=2, while complex 2 crystallizes in the orthorhombic space group Pbca with a=11.712(2), b=15.741(4), c=22.254(4) A, and Z=8. The [Cu(Imz)(4)Cl(2)][Cu(Imz)(4)Cl](2)(2-OH-Hip)(2) solid consists in two distinct monomeric Cu(II) complexes: one of them is neutral octahedral [Cu(Imz)(4)Cl(2)] and the other, charged square basis pyramida [Cu(Imz)(4)Cl](+). The 2-hydroxyhippuric acid, which here acts as a counter ion, is deprotonated at its carboxylic group. Cobalt(III) ion in [Co(2-OH-Hip)(Imz)(3)].H(2)O is at the center of an octahedral environment, coordinated to three Imidazol ligands and to a triply deprotonated 2-hydroxyhippuric acid molecule acting as a tridentate ligand. Aqueous solution equilibrium of the quaternary system Cu(2+)/2-OH-Hip/Imz/H(+) was studied by potentiometric titrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Cobalt / chemistry*
  • Cobalt / metabolism
  • Copper / chemistry*
  • Copper / metabolism
  • Hippurates / chemistry
  • Hippurates / metabolism
  • Hot Temperature
  • Hydrogen-Ion Concentration
  • Imidazoles / chemistry*
  • Imidazoles / metabolism
  • Ligands
  • Organometallic Compounds / chemistry*
  • Potentiometry
  • Spectrophotometry, Infrared

Substances

  • (Co(2-hydroxyhippuric acid)(imidazol)(3)).H(2)O (2)
  • (Cu(Imidazol)(4)Cl(2))(Cu(imidazole)(4)Cl)(2)(2-hydroxyhippuric acid)(2)
  • Hippurates
  • Imidazoles
  • Ligands
  • Organometallic Compounds
  • Cobalt
  • salicylurate
  • Copper