Abstract
The first synthesis of (+)- and (-)-akolactone A is described by using Pd-catalyzed carbonylation. A comparison of the optical rotation of both enantiomers of akolactone A and the natural compound suggests that the absolute configuration at the 4-position of akolactone A is R.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemical synthesis*
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Antineoplastic Agents / chemical synthesis*
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Catalysis
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Stereoisomerism
Substances
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Antineoplastic Agents
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akolactone A
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4-Butyrolactone