Refractory rhinosinusitis complicating immunosuppression: application of N-chlorotaurine, a novel endogenous antiseptic agent

ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):303-5. doi: 10.1159/000075231.

Abstract

Severe infections are a frequent complication in immunosuppression following transplantations. In the case reported here, a heart-transplanted patient was treated for refractory rhinosinusitis with a combination of sinus surgery and rinsing with N-chlorotaurine (NCT). The daily rinse was well tolerated and effective. The combination of functional endonasal sinus surgery and topical treatment with NCT appeared effective and well tolerated in antibiotic-resistant sinusitis under immunosuppression.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / therapeutic use*
  • Humans
  • Immunosuppression Therapy / adverse effects*
  • Inflammation Mediators / administration & dosage
  • Inflammation Mediators / therapeutic use
  • Male
  • Maxillary Sinus / surgery*
  • Otorhinolaryngologic Surgical Procedures
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / growth & development
  • Pseudomonas aeruginosa / pathogenicity
  • Rhinitis / drug therapy*
  • Rhinitis / microbiology
  • Rhinitis / surgery
  • Sinusitis / drug therapy*
  • Sinusitis / microbiology
  • Sinusitis / surgery
  • Taurine / administration & dosage
  • Taurine / analogs & derivatives*
  • Taurine / therapeutic use*
  • Therapeutic Irrigation

Substances

  • Anti-Infective Agents, Local
  • Inflammation Mediators
  • Taurine
  • N-chlorotaurine