Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB)

Planta Med. 2003 Nov;69(11):973-83. doi: 10.1055/s-2003-45141.

Abstract

Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-kappaB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Arachidonic Acid / metabolism*
  • Humans
  • NF-kappa B / metabolism*
  • Nitric Oxide Synthase / metabolism*
  • Phytotherapy*
  • Plants, Medicinal*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • NF-kappa B
  • Arachidonic Acid
  • Nitric Oxide Synthase