Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

Angew Chem Int Ed Engl. 2004 Jan 16;43(4):450-4. doi: 10.1002/anie.200352587.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Annexin A5 / analysis
  • Annexin A5 / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Apoptosis / physiology
  • Cell Division / drug effects
  • Cell Division / physiology
  • Cell Line
  • Cell Line, Transformed
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Cell Transformation, Neoplastic / genetics
  • Combinatorial Chemistry Techniques
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor / methods*
  • Epithelial Cells / drug effects
  • Genes, ras / drug effects*
  • Genes, ras / genetics
  • Genes, ras / physiology
  • Inhibitory Concentration 50
  • Microscopy, Fluorescence
  • Phenotype
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology
  • Structure-Activity Relationship
  • Sulindac / analogs & derivatives*
  • Sulindac / chemistry
  • Sulindac / pharmacology
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • Annexin A5
  • Anti-Inflammatory Agents, Non-Steroidal
  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Zebrafish Proteins
  • Sulindac