Abstract
Cell division requires the assembly of a microtubule-based spindle which captures and segregates sister chromatids. But how is this spindle broken down once chromosome segregation is complete? New evidence implicates a highly conserved AAA-ATPase in spindle disassembly at the end of mitosis.
MeSH terms
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Adenosine Triphosphatases
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Animals
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Cell Cycle Proteins / metabolism*
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Cell Division / physiology*
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Microtubule-Associated Proteins / metabolism
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Molecular Chaperones / metabolism
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Nuclear Pore Complex Proteins / metabolism
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Nucleocytoplasmic Transport Proteins
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Saccharomyces cerevisiae Proteins / metabolism
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Spindle Apparatus / metabolism*
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Spindle Apparatus / physiology
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Valosin Containing Protein
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Vesicular Transport Proteins
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Xenopus
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Yeasts
Substances
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Ase1 protein, S cerevisiae
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Cell Cycle Proteins
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Microtubule-Associated Proteins
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Molecular Chaperones
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NPL4 protein, S cerevisiae
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Nuclear Pore Complex Proteins
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Nucleocytoplasmic Transport Proteins
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Saccharomyces cerevisiae Proteins
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UFD1 protein, S cerevisiae
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Vesicular Transport Proteins
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Adenosine Triphosphatases
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CDC48 protein, S cerevisiae
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Valosin Containing Protein