Oxygenation of thiolates to S-bonded sulfinate in an iron III complex related to nitrile hydratase

Chem Commun (Camb). 2004 Feb 7:(3):286-7. doi: 10.1039/b312318a. Epub 2003 Dec 16.

Abstract

Air oxidation of the iron(III) complex derived from (2-mercaptoisobutyryl)-4,5-dichloro-O-phenylenediamine in the presence of Et4NCN afforded the corresponding disulfinato species. With two carboxamido nitrogens trans to two S-bonded sulfinates, this complex mimics the disulfinate inactive form of Fe-NHase.

MeSH terms

  • Ferric Compounds / metabolism*
  • Hydro-Lyases / metabolism*
  • Molecular Conformation
  • Molecular Structure
  • Oxidation-Reduction
  • Sulfhydryl Compounds / chemistry
  • Sulfhydryl Compounds / metabolism*
  • Sulfides / chemistry
  • Sulfides / metabolism*
  • Thermodynamics

Substances

  • Ferric Compounds
  • Sulfhydryl Compounds
  • Sulfides
  • Hydro-Lyases
  • nitrile hydratase