Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia

Taiwei Chu; Shaowen Hu; Bing Wei; Yi Wang; Xinqi Liu; Xiangyun Wang

doi:10.1016/j.bmcl.2003.11.017

Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia

Bioorg Med Chem Lett. 2004 Feb 9;14(3):747-9. doi: 10.1016/j.bmcl.2003.11.017.

Authors

Taiwei Chu¹, Shaowen Hu, Bing Wei, Yi Wang, Xinqi Liu, Xiangyun Wang

Affiliation

¹ Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

PMID: 14741282
DOI: 10.1016/j.bmcl.2003.11.017

Abstract

1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N4IPA) was synthesized. The biodistribution of 99mTc-N4IPA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that 99mTc-N4IPA would be a marker for imaging tumor hypoxia.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Hypoxia*
Male
Mice
Nitroimidazoles* / chemical synthesis
Organotechnetium Compounds* / chemical synthesis
Radionuclide Imaging
Sarcoma 180 / diagnostic imaging*
Tissue Distribution

Substances

Nitroimidazoles
Organotechnetium Compounds
4-nitroimidazole