The siderophore receptor IroN, but not the high-pathogenicity island or the hemin receptor ChuA, contributes to the bacteremic step of Escherichia coli neonatal meningitis

Valérie Lefranc Nègre; Stéphane Bonacorsi; Soren Schubert; Philippe Bidet; Xavier Nassif; Edouard Bingen

doi:10.1128/IAI.72.2.1216-1220.2004

The siderophore receptor IroN, but not the high-pathogenicity island or the hemin receptor ChuA, contributes to the bacteremic step of Escherichia coli neonatal meningitis

Infect Immun. 2004 Feb;72(2):1216-20. doi: 10.1128/IAI.72.2.1216-1220.2004.

Authors

Valérie Lefranc Nègre¹, Stéphane Bonacorsi, Soren Schubert, Philippe Bidet, Xavier Nassif, Edouard Bingen

Affiliation

¹ Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré (AP-HP), 75019 Paris, France.

Abstract

Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in the pathogenesis of Escherichia coli neonatal meningitis. Only IroN appeared to play a major role during the bacteremic step of the disease.

MeSH terms

Animals
Animals, Newborn
Bacteremia / etiology*
Bacterial Outer Membrane Proteins / genetics
Bacterial Outer Membrane Proteins / physiology*
Base Sequence
Escherichia coli / metabolism
Escherichia coli / pathogenicity*
Escherichia coli Infections / etiology*
Escherichia coli Proteins / genetics
Escherichia coli Proteins / physiology*
Iron / metabolism*
Meningitis, Bacterial / etiology*
Molecular Sequence Data
Rats
Rats, Sprague-Dawley
Receptors, Cell Surface / genetics
Receptors, Cell Surface / physiology*
Virulence

Substances

Bacterial Outer Membrane Proteins
ChuA protein, E coli
Escherichia coli Proteins
Receptors, Cell Surface
siderophore receptors
Iron